Preparation of celecoxib tablet by hot melt extrusion technology and application of process analysis technology to discriminate solubilization effect

Autor: Vanamane Renuka, Ilhwan Hwang, Ju-Hyun Lee, Jun-Bom Park, Beom-Jin Lee, Chin-Yang Kang, Kwon-Yeon Weon
Rok vydání: 2020
Předmět:
Zdroj: Pharmaceutical Development and Technology. 25:525-534
ISSN: 1097-9867
1083-7450
Popis: The aim of this study was to prepare various types of solid dispersions (SDs) by the hot-melt extrusion technique. Next, process analytical technology (PAT) such as Fourier transform-infrared (FT-IR) and Raman and near infrared (NIR) spectroscopy were applied to determine the solubilization effect. The SDs and its tablets were prepared. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were performed to determine the morphological and crystalline characteristics of the SDs. Additionally, PAT analyses were performed to identify the solubilization of the celecoxib. Dissolution testing was performed using the paddle method indicated in the US Pharmacopeia Apparatus II. Based on SEM, DSC, and XRD analysis, all SDs changed successfully from the crystalline to the amorphous form. However, FT-IR, Raman, and NIR analysis used in PAT showed that SDs were divided into two groups. New peaks formed as the amount of drug loading increased to50% in the SD and the dissolution rates were lower than those of the marketed drug. Drug loading levels of ≤50% showed no new peak and exhibited strong solubilization effects. PAT tools can be used to discriminate between extrudates with poor (50% drug release after 120 min) and desirable (75% drug release after 120 min) dissolution performance.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje