Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

Autor:	Seok Jin Kim, Young Hyeh Ko, Jung A Kim, Do-Hyun Nam, Kihyun Kim, Won Seog Kim, In-Gu Do, Juyoun Jin
Rok vydání:	2011
Předmět:	Adult Male Vascular Endothelial Growth Factor A Cancer Research Pathology medicine.medical_specialty Necrosis Central nervous system Mice Nude Antineoplastic Agents Biology Central Nervous System Neoplasms Immunoenzyme Techniques chemistry.chemical_compound Mice Young Adult hemic and lymphatic diseases medicine Biomarkers Tumor Animals Humans Hypoxia Aged Glucose Transporter Type 1 Mice Inbred BALB C Glucose transporter Primary central nervous system lymphoma Hematology Hypoxia (medical) Middle Aged medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Prognosis Xenograft Model Antitumor Assays Lymphoma Vascular endothelial growth factor Survival Rate medicine.anatomical_structure Oncology chemistry Female Lymphoma Large B-Cell Diffuse medicine.symptom Diffuse large B-cell lymphoma
Zdroj:	Leukemialymphoma. 52(2)
ISSN:	1029-2403
Popis:	Hypoxia-associated proteins are commonly expressed as a consequence of disturbances in microcirculation. However, the clinical relevance of the proteins has never been studied in primary central nervous system lymphoma (PCNSL). The expression of hypoxia-inducible factor 1α (HIF-1α) and its downstream proteins, vascular endothelial growth factor (VEGF) and glucose transporter 1 (GLUT-1), were evaluated in a central nervous system (CNS) lymphoma xenograft model and in human PCNSL tissue. In the CNS lymphoma xenograft model, the expression of HIF-1α, VEGF, and GLUT-1 co-localized in subsets of lymphoma cells adjacent to necrosis. In tumor specimens from 51 patients with PCNSL, positive HIF-1α staining was found in 26 patients (51.0%), positive VEGF in 30 (58.8%), and positive GLUT-1 in 17 (33.3%), and HIF-1α showed a significant correlation with VEGF (p 0.05). However, no significant association was seen between hypoxia-associated protein positivity and unfavorable clinical characteristics. Thus, the results failed to show an association with shorter overall survival or time to progression, except that the percentage of lymphoma cells positive for GLUT-1 (20%) was significantly associated with worse survival. In conclusion, hypoxia-associated proteins were expressed in PCNSL, suggesting a hypoxic microenvironment. However, the prognostic relevance of these proteins for PCNSL was not demonstrated in this study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a04d0f721ad9f2f7fbbc4feb266874 https://pubmed.ncbi.nlm.nih.gov/21281236 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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