Is the combined use of insulin resistance indices, including adipokines, more reliable in metabolic syndrome?
| Autor: | Birgül KURAL, Orhan DEĞER, Cihangir EREM, Fulya BALABAN YÜCESAN, Rezzan ALİYAZICIOĞLU, Yaşam BARLAK |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty medicine.medical_treatment Nicotinamide phosphoribosyltransferase Adipokine chemistry.chemical_compound Insulin resistance Adipokines Health Care Sciences and Services Internal medicine medicine Homeostasis Humans Sağlık Bilimleri ve Hizmetleri Nicotinamide Phosphoribosyltransferase Cerrahi Metabolic Syndrome Adiponectin business.industry Insulin Adiponectin insulin resistance metabolic syndrome leptin resistin visfatin General Medicine Middle Aged medicine.disease Endocrinology chemistry Resistin Metabolic syndrome Insulin Resistance business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Volume: 44, Issue: 6 1021-1028 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: To determine the levels of adipokines (leptin, adiponectin, resistin, and visfatin) and the indices of insulin sensitivity/ resistance, and to examine the relationship among them in patients with metabolic syndrome (MetS). Materials and methods: The study groups included 45 subjects with MetS (31 women/14 men), and 45 sex- and age-matched non-MetS healthy volunteers (31 women/14 men). The levels of adipokines were determined by enzyme-linked immunosorbent assay. Results: The levels of leptin and visfatin were significantly higher in the MetS than in the non-MetS subjects (P < 0.01). There was no difference in adiponectin levels in subjects with and without MetS (P = 0.052). Similarly, resistin did not show any statistically significant difference. A statistically significant positive correlation of leptin with insulin levels was observed, while negative correlations of visfatin levels with age, and resistin levels with the ratio of adiponectin to leptin, were found in the MetS (P < 0.05). The combination of adipokines, insulin resistance-sensitivity parameters, and MetS criteria parameters gave more significant differences than a single parameter. Conclusion: Since the parameters mentioned above might affect, interact with, and/or interfere with each other, the combinations of these parameters might give more reliable results to evaluate the insulin resistance/sensitivity in MetS patients. WOS:000344155900017 2-s2.0-84908079347 PubMed: 25552156 |
| Databáze: | OpenAIRE |
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