Treatment of Leptomeningeal Carcinomatosis in a Patient With Metastatic Cholangiocarcinoma
| Autor: | Nicole Adler, Joshua Smith, Frank M. Volpicelli, Alana E. Sigmund, Karin Warltier, Katherine Hochman, Aron Mednick, Charles Okamura, Ramon E. A. Jacobs, Katharine A. McNeill, Eduardo Iturrate, Benjamin Wertheimer |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Chemotherapy
medicine.medical_specialty medicine.diagnostic_test business.industry Lumbar puncture Leptomeninges medicine.medical_treatment Biliary Case Report Magnetic resonance imaging General Medicine Intrathecal digestive system digestive system diseases Catheter Medicine Methotrexate Radiology Headaches medicine.symptom business medicine.drug |
| Zdroj: | ACG Case Reports Journal |
| ISSN: | 2326-3253 |
| DOI: | 10.14309/crj.2014.78 |
| Popis: | A 49-year-old woman with cholangiocarcinoma metastatic to the lungs presented with new-onset unrelenting headaches. A lumbar puncture revealed malignant cells consistent with leptomeningeal metastasis from her cholangiocarcinoma. Magnetic resonance imaging (MRI) of the brain revealed leptomeningeal enhancement. An intrathecal (IT) catheter was placed and IT chemotherapy was initiated with methotrexate. Her case is notable for the rarity of cholangiocarcinoma spread to the leptomeninges, the use of IT chemotherapy with cytologic and potentially symptomatic response, and a possible survival benefit in comparison to previously reported cases of leptomeningeal carcinomatosis secondary to cholangiocarcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|