Pilot study assessing the Rotterdam Healthy Aging Score in a cohort of HIV-positive adults in Toronto, Canada
| Autor: | Sharon Walmsley, Rosemarie Clarke, Leah Szadkowski, Melody Ren, Ceylon Simon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Aging Canada Immunology pilot Human immunodeficiency virus (HIV) HIV Infections Pilot Projects medicine.disease_cause Health outcomes Healthy Aging 03 medical and health sciences 0302 clinical medicine Internal medicine Antiretroviral Therapy Highly Active Surveys and Questionnaires Multidimensional index cohort study Immunology and Allergy Medicine Humans 030212 general & internal medicine Cd4 cell count Healthy aging Depression (differential diagnoses) Aged Frailty business.industry Depression HIV health Clinical Science Middle Aged Antiretroviral therapy 030104 developmental biology Infectious Diseases Cross-Sectional Studies Mental Health Population Surveillance Cohort Female business |
| Zdroj: | AIDS (London, England) |
| ISSN: | 1473-5571 0269-9370 |
| Popis: | Objective The Rotterdam Healthy Aging Score (HAS) is a validated multidimensional index constructed from five health domains. We describe the HAS distribution in a cohort of HIV-positive adults and correlate it with health outcomes. Design A cross-sectional pilot study of 101 adults aged at least 40 years, on suppressive antiretroviral therapy attending a tertiary HIV clinic in Toronto, Canada. Methods Participants completed questionnaires to calculate their HAS (range 0-14). Demographics, HAS and sub-scores were compared by age and sex. The HAS was compared with results of the Fried Frailty Score, Short Performance Physical Battery score (SPPB) and measures of health utilization. Kruskal--Wallis Rank-Sum and Fisher's exact tests were used for all comparisons. Results Median (IQR) age was 56 (50--62), 81 (80%) men and 50 (50%) born in Canada. Median (IQR) CD4 cell count was 574 (417--794) cells/μl. Median (IQR) HAS was 12 (10--13) with 39 (39%) achieving a score more than 12 (considered healthy aging). Younger participants experienced more depression, whereas women had greater pain. The HAS score correlated with the Fried Frailty Score (P = 0.008) and trended with the SPPB Score (P = 0.077). Those with the poorest HAS scores were more likely to have been hospitalized in the preceding 6 months (P = 0.034). Conclusion The HAS ranged from 5 to 14 in this cohort of older HIV adults with 39% attaining scores in the 'healthy' range. The HAS correlated with measures of physical performance and health utilization. Further validation of an objective outcome in HIV-positive patients will facilitate evaluation of interventional studies to improve healthy aging. |
| Databáze: | OpenAIRE |
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