Long noncoding RNA amplified in lung cancer rewires cancer pathways
| Autor: | Nadya Dimitrova, Elena Martínez-Terroba |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell signaling
Lung Neoplasms DNA Copy Number Variations RNA biology Cell Adenocarcinoma of Lung Biology 03 medical and health sciences 0302 clinical medicine Antigens Neoplasm Cell Line Tumor Genetics medicine Humans Spotlight Lung cancer Cancer Cell Proliferation Immune Evasion 030304 developmental biology 0303 health sciences Immunogenicity NF-kappa B Oncogenes Cell Biology medicine.disease Long non-coding RNA Gene Expression Regulation Neoplastic medicine.anatomical_structure A549 Cells Carcinoma Squamous Cell Cancer research RNA Long Noncoding Ubiquitin-Specific Proteases 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.202007098 |
| Popis: | Martínez-Terroba and Dimitrova preview work from Athie et al., which demonstrates that the lncRNA ALAL-1 promotes lung cancer cell proliferation and immune evasion. Athie et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201908078) identify ALAL-1, a lncRNA frequently amplified or overexpressed in lung cancer, as an oncogenic driver, capable of promoting the proliferation and altering the immunogenicity of lung cancer cells. |
| Databáze: | OpenAIRE |
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