Molecular diversity and evolution of neuron types in the amniote brain
| Autor: | David Hain, Tatiana Gallego-Flores, Michaela Klinkmann, Angeles Macias, Elena Ciirdaeva, Anja Arends, Christina Thum, Georgi Tushev, Friedrich Kretschmer, Maria Antonietta Tosches, Gilles Laurent |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | The existence of evolutionarily conserved regions in the vertebrate brain is well established. The rules and constraints underlying the evolution of neuron types, however, remain poorly understood. To compare neuron types across brain regions and species, we generated a cell type atlas of the brain of a bearded dragon and compared it with mouse datasets. Conserved classes of neurons could be identified from the expression of hundreds of genes, including homeodomain-type transcription factors and genes involved in connectivity. Within these classes, however, there are both conserved and divergent neuron types, precluding a simple categorization of the brain into ancestral and novel areas. In the thalamus, neuronal diversification correlates with the evolution of the cortex, suggesting that developmental origin and circuit allocation are drivers of neuronal identity and evolution. |
| Databáze: | OpenAIRE |
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