Dental and craniofacial alterations in long-term survivors of childhood head and neck rhabdomyosarcoma
| Autor: | Denise Maria Araújo Magalhães, Sima Ferman, Valkiria D’Aiuto de Mattos, Simone De Queiroz Chaves Lourenço, Héliton Spíndola Antunes |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adolescent
medicine.medical_treatment Dentistry Pathology and Forensic Medicine Craniofacial Abnormalities Young Adult 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Rhabdomyosarcoma medicine Dentition Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Survivors Craniofacial Child business.industry Soft tissue sarcoma Infant Newborn Infant Chemoradiotherapy 030206 dentistry Craniometry medicine.disease Combined Modality Therapy Radiation therapy Cross-Sectional Studies Head and Neck Neoplasms Child Preschool 030220 oncology & carcinogenesis Surgery Oral Surgery business Facial symmetry |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 127:272-281 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2018.12.012 |
| Popis: | Objective Rhabdomyosarcoma (RMS) represents the most common soft tissue sarcoma that affects children. Treatment involves chemoradiotherapy. This study aimed at evaluating the long-term alterations to teeth and cranial bones in children, teenagers, and young adults after oncologic treatment. Study Design We conducted a cross-sectional study of patients undergoing treatment for head and neck RMS between 1988 and 2011. We evaluated demographic, clinical, and treatment data and performed panoramic radiography, cephalometry, and photography. Results We evaluated 27 long-term survivors, most of whom had been treated between ages 0 to 5 years (51.9%). The total radiation dose applied was 50.4 Gy, and the chemotherapy combination included vincristine, actinomycin D, and cyclophosphamide in 51.9% of the cases. We observed 603 dental alterations, among which 377 (62.7%) occurred in patients ages 0 to 5 years, and root shortening was the most frequent alteration observed (24.2%). With regard to facial bones, 74% of the patients had some level of facial asymmetry, 70.4% had reduced facial depth, 48.4% had mandibles of short size, and 77.8% had reduced facial height. Conclusions Children submitted to RMS treatment involving chemotherapy and radiotherapy displayed significant dental and craniofacial alterations, especially when treatment occurred between ages 0 and 5 years. |
| Databáze: | OpenAIRE |
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