Gastric Mucosal Necrosis With Vascular Degeneration Induced by Doxycycline
| Autor: | Lei Zhao, Carol E. Semrad, John Hart, Shu-Yuan Xiao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology Necrosis Degenerative change Gastroenterology Pathology and Forensic Medicine Internal medicine medicine Esophagitis Humans Normal gastric mucosa Endoscopy Digestive System Aged Aged 80 and over Peripheral Vascular Diseases Doxycycline medicine.diagnostic_test Esophagogastroduodenoscopy business.industry Remission Induction EPIGASTRIC ABDOMINAL PAIN Abdominal Pain Anti-Bacterial Agents Capillaries Treatment Outcome Withholding Treatment Gastric Mucosa Toxicity Vascular degeneration Female Surgery Anatomy medicine.symptom business medicine.drug |
| Zdroj: | American Journal of Surgical Pathology. 37:259-263 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0b013e31826602d8 |
| Popis: | We encountered 2 patients who underwent esoph-agogastroduodenoscopy for epigastric abdominal pain, whichshowed gastric mucosal erosions covered with adherent exudate.Microscopic examination of biopsies from the lesions obtainedfrom the 2 cases revealed characteristic pathologic abnormalitiesthat shared striking similarities. These included superficial mu-cosal necrosis and capillary vascular degenerative change in abackground of reactive or chemical gastropathy. Further reviewof records identified ongoing oral doxycycline use in both pa-tients. After cessation of the drug both patients’ symptoms re-solved. A follow-up esophagogastroduodenoscopy in 1 patientshowed normal gastric mucosa. This pattern of injury had notbeen previously described and seems to be characteristic fordoxycycline-induced gastric mucosal toxicity. Recognition of theclinical, endoscopic, and pathologic features described here mayfacilitate prompt diagnosis and management of this condition.Key Words: doxycycline, gastric ulcer, erosion, drug-induced,gastropathy, toxic-ischemic, vascular degeneration(Am J Surg Pathol 2013;37:259–263) |
| Databáze: | OpenAIRE |
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