Cost-effectiveness analysis of pembrolizumab versus chemotherapy as first-line treatment in locally advanced or metastatic non-small cell lung cancer with PD-L1 tumor proportion score 1% or greater
Autor: | Yin Shi, Youwen Zhu, Dong Ding, Shan Zeng, David P. Carbone, Longjiang She, Linli Yao, Liangfang Shen, Xuefeng Xia, Mengting Liao, Huabin Hu, Jin Huang |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology Male Cancer Research medicine.medical_specialty Lung Neoplasms Cost effectiveness medicine.medical_treatment Cost-Benefit Analysis Subgroup analysis Pembrolizumab Antibodies Monoclonal Humanized B7-H1 Antigen Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological Internal medicine Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols medicine Anaplastic lymphoma kinase Humans Neoplasm Metastasis Lung cancer Aged Chemotherapy business.industry Cost-effectiveness analysis medicine.disease Markov Chains United States Quality-adjusted life year 030104 developmental biology 030220 oncology & carcinogenesis Disease Progression Female Quality-Adjusted Life Years business |
Zdroj: | Lung cancer (Amsterdam, Netherlands). 138 |
ISSN: | 1872-8332 |
Popis: | Objective The purpose of this study was to estimate the cost-effectiveness analysis of pembrolizumab versus chemotherapy as first-line treatment in locally advance or metastatic non-small cell lung cancer (NSCLC) with programmed death ligand 1 (PD-L1) tumor proportion score (TPS) 1% or greater from the United States (US) payer perspective. Materials and Methods This Markov structure was developed to estimate cost and effectiveness of pembrolizumab vs chemotherapy in the first-line treatment of locally advance or metastatic NSCLC based on the data from KEYNOTE-042. Cost and health outcomes were estimated at a willingness-to-pay (WTP) threshold of $150,000 per quality adjusted life year (QALY) in three PD-L1 TPS populations (≥50%, ≥20% and ≥1%). One-way, two-way and probabilistic sensitivity analysis were to test the model stability. Subgroup analysis were performed in three PD-L1 TPS populations (≥50%, ≥20% and ≥1%). Results The incremental costs and QALYs that pembrolizumab yielded, compared with chemotherapy, were $86164.87 and 0.63, $74562.25 and 0.46 and $70886.65 and 0.39 for the populations with a PD-L1 TPS ≥ 50%, TPS ≥ 20% and TPS ≥ 1%, leading an incremental cost-effective ratio (ICER) of $136,228.82, $160,625.98 and $179,530.17 per QALY, respectively. Conclusion First-line treatment with pembrolizumab is a cost-effective strategy compared with platinum-based chemotherapy when the value of WTP was $150,000 per QALY in locally advanced or metastatic NSCLC patients with PD-L1 TPS ≥ 50% and without epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations, but not in the TPS ≥ 20% and 1% populations. |
Databáze: | OpenAIRE |
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