Action of a beta-bungarotoxin on autonomic ganglia and adrenergic neurotransmission
| Autor: | A. C. Kato, J. E. B. Pinto, B. Collier, M. Glavinović |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Sympathetic Nervous System Physiology Autonomic ganglion Diaphragm Guinea Pigs Neuromuscular transmission Neuromuscular Junction Adrenergic Action Potentials Biology Neurotransmission In Vitro Techniques Motor Endplate Synaptic Transmission Ileum Physiology (medical) Internal medicine Ganglia Spinal medicine Animals Nictitating Membrane Ganglia Autonomic Pharmacology Muscle Smooth General Medicine Bungarotoxin Bungarotoxins Sympathetic ganglion Myocardial Contraction Acetylcholine Rats Endocrinology medicine.anatomical_structure Cats Cholinergic Spleen medicine.drug Muscle Contraction |
| Zdroj: | Canadian journal of physiology and pharmacology. 55(3) |
| ISSN: | 0008-4212 |
| Popis: | A β-bungarotoxin was isolated from the venom of Bungarus multicinctus by column chromatography on Sephadex G-50 and SP-Sephadex. The toxin produced presynaptic effects on neuromuscular transmission with characteristics similar to those described by others. In a sympathetic ganglion, the toxin increased spontaneous acetylcholine (ACh) release and decreased ACh release evoked by preganglionic nerve stimulation. The toxin did not block the response of isolated ileum to cholinergic nerve stimulation, did not block the release of noradrenaline from the adrenergic nerve terminals of a nictitating membrane preparation, and did not alter the responses of smooth and cardiac muscle preparations to noradrenaline. It is suggested that the specificity of β-bungarotoxin for certain nerve terminals is related either to selective binding of the toxin or to the selective presence of a necessary substrate for its action. An attempt to show selective binding of 125I-toxin to cholinergic nerve terminals in skeletal muscle was not successful. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|