Synthesis of 2-phosphonoheterocycles via base-promoted 5-endo cyclization

Autor:	Laurent El-Kaïm, Mohamed Lamine Benkhoud, Sébastien Prévost, Ameni Bousbia
Přispěvatelé:	Laboratoire de Physicochimie des Matériaux - IPEST(La Marsa, Tunisia), Institut préparatoire aux études scientifiques et techniques [La Marsa] (IPEST), Institut Polytechnique de Paris (IP Paris)
Rok vydání:	2021
Předmět:	chemistry 010405 organic chemistry Potassium Organic Chemistry Drug Discovery [CHIM]Chemical Sciences chemistry.chemical_element 010402 general chemistry Base (exponentiation) 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences
Zdroj:	Tetrahedron Letters Tetrahedron Letters, Elsevier, 2021, 64, pp.152742. ⟨10.1016/j.tetlet.2020.152742⟩
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2020.152742
Popis:	International audience; Herein, a synthesis of 2-phosphonodihydrofurans and 2-phosphonodihydropyrroles via 5-endo cyclization of O-and N-propargylated compounds is described. The reaction is promoted by potassium tert-butoxide and allows a fast access to interesting heterocycles which were easily converted into 2-arylated pyrroles under acidic conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9692bbaede6ff404af6800909bb54bfa https://doi.org/10.1016/j.tetlet.2020.152742 Zobrazit plný text záznamu Full Text from ScienceDirect