Chiral separation of amino acids derivatised with fluorescein isothiocyanate by single isomer derivatives 3-monodeoxy-3-monoamino-β- and γ-cyclodextrins: the effect of the cavity size
| Autor: | Giuseppe Maccarrone, Rosario Caruso, Alejandro Cifuentes, Marianna Messina, Vincenzo Cucinotta, Alessandro Giuffrida, Annalinda Contino |
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| Rok vydání: | 2012 |
| Předmět: |
Cavity size
Resolution (mass spectrometry) Stereochemistry Biochemistry Analytical Chemistry Capillary electrophoresis chemistry.chemical_compound Capillary Electrophoresis Cyclodetrin derivatives Molecular Recognition Chiral Separation Amino acids Fluorescein isothiocyanate chemistry.chemical_classification Cyclodextrins Chromatography Organic Chemistry Electrophoresis Capillary Stereoisomerism General Medicine Chiral separation Single isomer Amino acid chemistry Cyclodextrin derivatives Molecular recognition Enantiomer Fluorescein-5-isothiocyanate |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0021-9673 |
| Popis: | Thirteen enantiomeric pairs of α-amino acids derivatised with fluorescein isothiocyanate (FITC-AAs) were separated in capillary electrophoresis (CE) using as chiral selectors the single isomer derivatives (SIDs) 3-monodeoxy-3-monoamino-β- and γ-cyclodextrins. The chiral separation data obtained by these strictly homologous compounds, show different behaviours, allowing to hypothesise a possible structure of the obtained selector-analyte complexes, as well as highlighting the crucial role of the cavity size and the significant effects on the resolution obtained by small differences in the structural characteristics of these analytes. © 2012 Elsevier B.V. |
| Databáze: | OpenAIRE |
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