Trace elements and oxidative stress in children with type 1 diabetes mellitus
| Autor: | Ashgan A. Alghobashy, Usama M. Alkholy, Randa H. Mohamed, Mohamed A Talat, Ihab A. Ahmed, Ahmed A. Zaki, Nermin Abdalmonem |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
trace elements chemistry.chemical_element peroxidase 030209 endocrinology & metabolism Carbohydrate metabolism medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Internal Medicine medicine oxidative stress 030212 general & internal medicine reduced glutathione Targets and Therapy [Diabetes Metabolic Syndrome and Obesity] Original Research Glycemic Pharmacology Type 1 diabetes business.industry Glutathione medicine.disease type 1diabetes Endocrinology chemistry Hemoglobin business Oxidative stress Selenium |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| ISSN: | 1178-7007 |
| Popis: | Ashgan Abdalla Alghobashy,1 Usama M Alkholy,1 Mohamed A Talat,1 Nermin Abdalmonem,1 Ahmed Zaki,2 Ihab A Ahmed,1 Randa H Mohamed3 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 2Department of Pediatrics, Faculty of Medicine, Mansura University, Mansura, Egypt; 3Department of Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt Background: The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D. Methods: A case–control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group. The diabetic children were divided into poor and good controlled patients according to glycosylated hemoglobin (A1c %). Studied children underwent history taking, clinical examination and laboratory measurement of serum Se, Zn, Mg, and Cu levels, erythrocyte reduced glutathione (GSH) and peroxidase enzyme activity (GPx). Results: Serum Se, Zn, Mg, Cu, erythrocyte GSH, and GPx were significantly lower in the diabetic group in comparison to the control group (P |
| Databáze: | OpenAIRE |
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