New Compound Classes: Protein–Protein Interactions
| Autor: | Ottmann, C., Nielsch, U., Fuhrmann, U., Jaroch, S. |
|---|---|
| Přispěvatelé: | Chemical Biology |
| Rok vydání: | 2015 |
| Předmět: |
PPI stabilization
Natural products Drug discovery Druggability Small Molecule Libraries Computational biology Human physiology Biology Pharmacology SDG 3 – Goede gezondheid en welzijn Protein–protein interaction Protein stability SDG 3 - Good Health and Well-being Small-molecules PPI inhibition X-ray crystallography |
| Zdroj: | New Approaches to Drug Discovery ISBN: 9783319289120 Handbook of Experimental Pharmacology, 232, 125-138 |
| DOI: | 10.1007/164_2015_30 |
| Popis: | “Protein–protein interactions (PPIs) are one of the most promising new targets in drug discovery. With estimates between 300,000 and 650,000 in human physiology, targeted modulation of PPIs would tremendously extend the “druggable” genome. In fact, in every disease a wealth of potentially addressable PPIs can be found making pharmacological intervention based on PPI modulators in principle a generally applicable technology. An impressing number of success stories in small-molecule PPI inhibition and natural-product PPI stabilization increasingly encourage academia and industry to invest in PPI modulation. In this chapter examples of both inhibition as well as stabilization of PPIs are reviewed including some of the technologies which has been used for their identification.” |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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