Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Autor: | Deborah Pugin, Victor Montaut, Simone Madigan, Olivier Clerc, Laurence Haesler |
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Rok vydání: | 2020 |
Předmět: |
Coma
Pediatrics medicine.medical_specialty business.industry medicine.drug_class Sedation Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Encephalopathy severe acute respiratory syndrome coronavirus 2 infection Case Report coma Inflammation General Medicine encephalopathy medicine.disease corticosteroids Regimen inflammation Medicine Corticosteroid Respiratory system medicine.symptom business |
Zdroj: | Critical Care Explorations |
ISSN: | 2639-8028 |
Popis: | Background: Responsible for the coronavirus disease 2019 pandemic that began in December 2019, severe acute respiratory syndrome coronavirus 2 mainly causes respiratory insult. Few cases were reported of extrapulmonary involvement, many of which were neurologic. Case Summary: In this case report, we present two cases of prolonged coma after weaning off sedation in severe acute respiratory syndrome coronavirus 2 patients with rapid neurologic improvement shortly after high-dose corticosteroid regimen. Conclusions: We thus hypothesize an inflammatory process being responsible for the prolonged coma. Inflammatory neurologic insult has been described with other coronaviruses. Further studies are needed to determinate the extent and underlying mechanism of neurologic involvement in severe acute respiratory syndrome coronavirus 2 infections. |
Databáze: | OpenAIRE |
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