Overexpression of Survivin‑1, TAG‑72 and HERC5 in patients diagnosed with hepatocellular carcinoma in the Black Sea coast geographical area
| Autor: | Vlad Herlea, Andra-Iulia Suceveanu, Costel Brînzan, Laura Mazilu, Florin Botea, Cornelia Nitipir, Gabriela-Izabela Baltatescu, Adrian Paul Suceveanu, Nicolae Dobrin, Felix Voinea, Ioan Sergiu Micu, Lucian Cristian Petcu |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine Ascites Survivin medicine neoplasms Receiver operating characteristic business.industry Incidence (epidemiology) Cancer Articles General Medicine Guideline medicine.disease digestive system diseases 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Immunohistochemistry medicine.symptom business |
| Zdroj: | Exp Ther Med |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Epidemiological data regarding hepatocellular carcinoma (HCC) report unsatisfactory morbimortality rates despite the global efforts to decrease the incidence and prolong patient survival. Current guidelines lack diagnostic biomarkers to better characterize patients with HCC. We aimed to validate the overexpression of Survivin-1, tumor-associated glyocoprotein 72 (Tag-72), and HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5) as tissue biomarkers for HCC characterization in patients from our geographical area and to standardize a local biomarker panel to be introduced in the current management guideline. Thirty samples of histologically confirmed HCC were compared to an equal number of samples of benign tumors in terms of Survivin-1, TAG-72, and HERC5 overexpression. Student's t-test, Mann-Whitney U test and Chi-square test were used to find differences between the two studied groups and to compare the categorical variables. The discriminative power of Survivin-1, Tag-72, and HERC5 overexpression was assessed using ROC curves. The multivariate linear regression analysis revealed that Survivin, Tag-72, and HERC5 were significantly overexpressed in older male patients, with α-fetoprotein (AFP) >200 ng/dl, low serum albumin, as well as in patients with imaging features of portal thrombosis and ascites. The diagnostic performance of Survivin-1, Tag-72 and HERC5 tissue biomarkers for HCC characterization was superior to that of the gold-standard AFP. Our study results validate the overexpression of Survivin-1, Tag-72, and HERC5 as tissue biomarkers for HCC characterization in patients from our geographical region and could be standardized in the current HCC management guideline. |
| Databáze: | OpenAIRE |
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