Intrathoracic and extrathoracic skeletal muscle ventricles in circulation: left ventricular apex-to-aorta configuration
| Autor: | Hidehiro Nakajima, Robert Fietsam, Larry W. Stephenson, Hisako Nakajima, Huiplng Lu, Michael Colson, L B A Robert Hammond, Susumu Isoda, Gregory A. Thomas |
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| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Cardiac output Heart Ventricles Diastole Hemodynamics Aorta Thoracic Blood Pressure Pulmonary Artery Surgical Flaps Dogs Blood vessel prosthesis medicine.artery Internal medicine medicine Ventricular Pressure Thoracic aorta Animals Assisted Circulation Cardiac Output Polytetrafluoroethylene Aorta business.industry Polyethylene Terephthalates Muscles Anastomosis Surgical Thoracic Surgery Stroke Volume Stroke volume Anatomy Blood Vessel Prosthesis Electrodes Implanted Regional Blood Flow Ventricular pressure Cardiology Surgery Cardiology and Cardiovascular Medicine business Follow-Up Studies Muscle Contraction |
| Zdroj: | Journal of cardiac surgery. 9(3) |
| ISSN: | 0886-0440 |
| Popis: | Skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle in 12 dogs. In group I (n = 6), SMVs were placed intrathoracic, in the apex of the left hemithorax. In group II (n = 6), SMVs were positioned extrathoracic between the chest wall and subcutaneous tissue. After a 3-week vascular delay period, SMVs were electrically pre-conditioned with 2-Hz continuous stimulation for 6 weeks. At a second procedure, a valved conduit was placed between the left ventricular (LV) apex and the SMV, and a second valved conduit between the SMV and the thoracic aorta. The SMVs were stimulated to contract during diastole at a 1:2 ratio with the heart. In group I, SMVs generated peak pressures of 91 +/- 10 mmHg, pumped 47% of the systemic blood flow (0.73 +/- 0.25 vs 1.54 +/- 0.42 L/min; p < 0.05), and produced a 25% decrease in the LV systolic tension-time index (TTI) (16.9 +/- 2.7 vs 12.5 +/- 3.3 mmHg.sec; p < 0.05). In group II, SMV peak pressure was 93 +/- 10 mmHg, SMVs pumped 51% of the systemic blood flow (0.78 +/- 0.10 vs 1.53 +/- 0.42 L/min; p < 0.05), and the LV systolic TTI decreased 29% (14.0 +/- 0.8 vs 9.9 +/- 2.0 mmHg.sec; p < 0.05). There was no significant difference between group I and II. These data indicate that the SMV:LV apex-to-aorta configuration is the most effective method reported to date for skeletal muscle cardiac assist. Extrathoracic and intrathoracic SMVs functioned equally well after connection to the circulation. |
| Databáze: | OpenAIRE |
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