Hypertensive pathologies and egg donation pregnancies: Results of a large comparative cohort study

Autor: Florence Scheffler, Isabelle Cedrin-Durnerin, Hélène Letur, Jacques de Mouzon, Maëliss Peigné, Emmanuelle Mathieu-D’Argent, Jeanine Ohl, Veronika Grzegorczyk-Martin
Přispěvatelé: Institut Mutualiste de Montsouris (IMM), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Centre Hospitalier Universitaire de Strasbourg (CHU de Strasbourg ), Service d’Histologie-Embryologie-Cytogénétique-CECOS, Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie
Rok vydání: 2016
Předmět:
Adult
medicine.medical_specialty
Pregnancy Rate
egg donation
[SDV]Life Sciences [q-bio]
medicine.medical_treatment
Blood Pressure
Fertilization in Vitro
Risk Assessment
eclampsia
Preeclampsia
preeclampsia
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
pregnancy induced hypertension
medicine
Odds Ratio
Humans
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Retrospective Studies
Gynecology
030219 obstetrics & reproductive medicine
Assisted reproductive technology
Eclampsia
Chi-Square Distribution
Oocyte Donation
Obstetrics
business.industry
Age Factors
Obstetrics and Gynecology
Retrospective cohort study
Odds ratio
Hypertension
Pregnancy-Induced
medicine.disease
Logistic Models
Treatment Outcome
Reproductive Medicine
Multivariate Analysis
Female
business
Infertility
Female
Hypertensive pathologies
Cohort study
Zdroj: Fertility and Sterility
Fertility and Sterility, 2016, 106 (2), pp.284-290. ⟨10.1016/j.fertnstert.2016.03.031⟩
ISSN: 1556-5653
0015-0282
Popis: International audience; Objective: To determine whether egg donation (ED) pregnancies are at higher risk of pregnancy-induced hypertension (PIH) than those achieved by autologous assisted reproductive technology (ART; controls). Design: Anonymous comparative observational matched cohort study. Setting: Assisted reproductive technology centers. Patient(s): Two hundred seventeen ED and 363 control singleton pregnancies matched at 7-8 weeks (pregnancy date, parity, cycle type [fresh/frozen] and women's age). According to French practice, all women were under 45. Intervention(s): None. Main Outcome Measure(s): Percentage of PIH for ED versus controls. Result(s): The groups were comparable (mean age, 34.5). PIH was more frequent during ED pregnancies (17.8% vs. 5.3%), as was preeclampsia (11.2% vs. 2.8%) and eclampsia (1.8% vs. 0.0%). In multivariate analyses, PIH risk increased with ED (odds ratio [OR], 3.92; 95% confidence interval [CI], 1.93-7.97) and women's age (OR, 1.08; 95% CI, 1.00-1.16). No significant effect of previous pregnancies or cycle rank/type was observed. Conclusion(s): This study had sufficient power to detect doubling of the PIH rate. It was demonstrated that the risk of PIH was tripled for ED versus controls. Even in young women, ED is a risk factor for PIH. An immunological explanation seems most likely, that is, the fetus is fully allogeneic to its mother. This risk must be acknowledged to inform couples and provide careful pregnancy monitoring. (C) 2016 by American Society for Reproductive Medicine.
Databáze: OpenAIRE
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