Cytoplasmic Colocalization of RXRα and PPARγ as an Independent Negative Prognosticator for Breast Cancer Patients
| Autor: | Wanting Shao, Melitta B. Köpke, Theresa Vilsmaier, Alaleh Zati Zehni, Mirjana Kessler, Sophie Sixou, Mariella Schneider, Nina Ditsch, Vincent Cavaillès, Udo Jeschke |
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| Přispěvatelé: | University-Hospital Munich-Großhadern [München], Zhejiang University, Klinikum Augsburg, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Herrada, Anthony |
| Rok vydání: | 2022 |
| Předmět: |
Cytoplasm
PPARγ survival analyses [SDV.CAN]Life Sciences [q-bio]/Cancer Breast Neoplasms MESH: Retinoid X Receptor alpha breast cancer [SDV.CAN] Life Sciences [q-bio]/Cancer [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] RXRα Humans nuclear receptor ddc:610 Retrospective Studies MESH: Humans Retinoid X Receptor alpha MESH: Cytoplasm MESH: Retrospective Studies General Medicine cytoplasmic expression PPAR gamma MESH: PPAR gamma [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Female MESH: Female MESH: Breast Neoplasms |
| Zdroj: | Cells Cells, 2022, 11 (7), pp.1244. ⟨10.3390/cells11071244⟩ Cells; Volume 11; Issue 7; Pages: 1244 |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells11071244 |
| Popis: | Retinoid X receptor α (RXRα) is a nuclear receptor (NR) which functions as the primary heterodimeric partner of other NRs including the peroxisome proliferator-activated receptor γ (PPARγ). We previously reported that, in breast cancers (BC), the subcellular localization of these two receptors was strongly associated with patient prognosis. In the present work, we investigated the prognosis value of the combined cytoplasmic expression of RXRα and PPARγ using a retrospective cohort of 250 BC samples. Patients with tumors expressing both NRs in tumor cell cytoplasm exhibited a significant shorter overall (OS) and disease-free survival (DFS). This was also observed for patients with stage 1 tumors. Cox univariate analysis indicated that patients with tumors coexpressing RXRα and PPARγ in the cytoplasm of tumor cells have a decreased 5 y OS rate. Cytoplasmic co-expression of the two NRs significantly correlated with HER2 positivity and with NCAD and CD133, two markers of tumor aggressiveness. Finally, in Cox multivariate analysis, the co-expression of RXRα and PPARγ in the cytoplasm appeared as an independent OS prognosticator. Altogether, this study demonstrates that the cytoplasmic co-expression of RXRα and PPARγ could be of relevance for clinicians by identifying high-risk BC patients, especially amongst those with early and node-negative disease. |
| Databáze: | OpenAIRE |
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