IMPACT OF PERMETHRIN-TREATED BED NETS ON MALARIA AND ALL-CAUSE MORBIDITY IN YOUNG CHILDREN IN AN AREA OF INTENSE PERENNIAL MALARIA TRANSMISSION IN WESTERN KENYA: CROSS-SECTIONAL SURVEY
| Autor: | Arthur M. Kwena, Margarette S. Kolczak, William A. Hawley, Ya Ping Shi, Dianne J. Terlouw, John M. Vulule, Penelope A. Phillips-Howard, Jennifer F. Friedman, Feiko O. ter Kuile, Simon Kariuki, Bernard L. Nahlen |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Respiratory tract infections business.industry Holoendemic Population medicine.disease Surgery Child mortality Infectious Diseases Virology Environmental health parasitic diseases Epidemiology Medicine Mosquito net Parasitology business education Malaria Permethrin medicine.drug |
| Zdroj: | American journal of tropical medicine and hygiene, 68(4 Suppl), 100-107. American Society of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Information on the impact of insecticide (permethrin)-treated bed nets (ITNs) from randomized controlled trials in areas of intense perennial malaria transmission is limited. As part of a large-scale, community-based, group-randomized controlled trial of the effect of ITNs on childhood mortality in a holoendemic area in western Kenya, we conducted three cross-sectional surveys in 60 villages to assess the impact of ITNs on morbidity in 1,890 children less than three years old. Children in ITN and control villages were comparable pre-intervention, but after the introduction of ITNs, children in intervention villages were less likely to have recently experienced illness requiring treatment (protective efficacy [95% confidence intervals] = 15% [1-26%]), have an enlarged spleen (32% [20-43%]), be parasitemic (19% [11-27%]), have clinical malaria (44% [6-66%]), have moderately severe anemia (hemoglobin level < 7.0 g/dL; 39% [18-54%]), or have a pruritic body rash, presumably from reduced nuisance insect bites (38% [24-50%]). Use of ITNs was also associated with significantly higher mean weight-for-age Z-scores and mid-upper arm circumferences. There was no evidence, however, that ITNs reduced the risk of helminth infections, diarrhea, or upper or lower respiratory tract infections. The ITNs substantially reduced malaria-associated morbidity and improved weight gain in young children in this area of intense perennial malaria transmission. |
| Databáze: | OpenAIRE |
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