| Autor: |
Nathan Harris, Samuel Bates, Zihao Zhuang, Matthew Bernstein, Jamie Stonemetz, Tyler Hill, Yanxun V. Yu, John A. Calarco, Piali Sengupta |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Current Biology. 33:1487-1501.e7 |
| ISSN: |
0960-9822 |
| Popis: |
Neurons modify their transcriptomes in response to an animal’s experience. How specific experiences are transduced to modulate gene expression and precisely tune neuronal functions are not fully defined. Here, we describe the molecular profile of a thermosensory neuron pair inC. elegansexperiencing different temperature stimuli. We find that distinct salient features of the temperature stimulus including its duration, magnitude of change, and absolute value are encoded in the gene expression program in this single neuron, and identify a novel transmembrane protein and a transcription factor whose specific transcriptional dynamics are essential to drive neuronal, behavioral, and developmental plasticity. Expression changes are driven by broadly expressed activity-dependent transcription factors and correspondingcis-regulatory elements that nevertheless direct neuron- and stimulus-specific gene expression programs. Our results indicate that coupling of defined stimulus characteristics to the gene regulatory logic in individual specialized neuron types can customize neuronal properties to drive precise behavioral adaptation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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