Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia
| Autor: | Francis Eustache, Vincent de la Sayette, Mickaël Laisney, Catherine Merck, Béatrice Desgranges, Gaël Chételat, Brigitte Landeau, Alexandre Bejanin, Serge Belliard, Alice Pélerin |
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| Přispěvatelé: | Neuropsychologie et imagerie de la mémoire humaine (NIMH), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Service de Neurologie [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de Neurologie [CHU Rennes], CHU Pontchaillou [Rennes], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Social Psychology Rest Theory of Mind Semantic dementia Development Neuropsychological Tests Affect (psychology) 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cognition Social cognition Functional neuroimaging Theory of mind Neural Pathways medicine Semantic memory Humans 0501 psychology and cognitive sciences Cognitive Dysfunction ComputingMilieux_MISCELLANEOUS Aged [SCCO.NEUR]Cognitive science/Neuroscience 05 social sciences Brain Organ Size medicine.disease Affect Social Perception Frontotemporal Dementia [SCCO.PSYC]Cognitive science/Psychology Female Atrophy Psychology Neuroscience 030217 neurology & neurosurgery Cognitive psychology Frontotemporal dementia |
| Zdroj: | Social Neuroscience Social Neuroscience, Taylor & Francis (Routledge), 2016, 12 (3), pp.287-302. ⟨10.1080/17470919.2016.1168314⟩ |
| ISSN: | 1747-0919 1747-0927 |
| DOI: | 10.1080/17470919.2016.1168314⟩ |
| Popis: | Using structural MRI, we investigated the brain substrates of both affective and cognitive theory of mind (ToM) in 19 patients with semantic dementia. We also ran intrinsic connectivity analyses to identify the networks to which the substrates belong and whether they are functionally disturbed in semantic dementia. In line with previous studies, we observed a ToM impairment in patients with semantic dementia even when semantic memory was regressed out. Our results also highlighted different neural bases according to the nature (affective or cognitive) of the representations being inferred. The affective ToM deficit was associated with atrophy in the amygdala, suggesting the involvement of emotion-processing deficits in this impairment. By contrast, cognitive ToM performances were correlated with the volume of medial prefrontal and parietal regions, as well as the right frontal operculum. Intrinsic connectivity analyses revealed decreased functional connectivity, mainly between midline cortical regions and temporal regions. They also showed that left medial temporal regions were functionally isolated, a further possible hindrance to normal social cognitive functioning in semantic dementia. Overall, this study addressed for the first time the neuroanatomical substrates of both cognitive and affective ToM disruption in semantic dementia, highlighting disturbed connectivity within the networks that sustain these abilities. |
| Databáze: | OpenAIRE |
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