Prevalence and Predictors of Hospitalizations Among HIV-Infected and At-Risk HIV-Uninfected Women
| Autor: | Anna L. Hotton, Deborah Gustafson, Kathryn Anastos, Mardge H. Cohen, Elizabeth T. Golub, Mary Young, Alexandra M. Levine, Kathleen M. Weber, Ronald C. Hershow, Peter Bacchetti |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pediatrics HIV Infections Article 03 medical and health sciences 0302 clinical medicine Internal medicine Antiretroviral Therapy Highly Active medicine Prevalence Humans Pharmacology (medical) 030212 general & internal medicine Proportional Hazards Models Proportional hazards model business.industry Hazard ratio Hepatitis C Viral Load medicine.disease 030112 virology Confidence interval CD4 Lymphocyte Count Hospitalization Infectious Diseases Population Surveillance Coinfection Female New York City business Viral load Psychosocial Cohort study |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 75(2) |
| ISSN: | 1944-7884 |
| Popis: | OBJECTIVES We evaluated the Veterans Aging Cohort Study (VACS) Index score, an index composed of age, CD4 count, viral load, hemoglobin, Hepatitis C coinfection, Fibrosis Index-4, and estimated glomerular filtration rate, and psychosocial and clinical risk factors for all-cause hospitalization among HIV-infected women on highly active antiretroviral therapy and HIV-uninfected women. METHODS Data were collected from 2008 to 2014 from 1585 highly active antiretroviral therapy-experienced HIV infected and 692 uninfected women. Cox proportional hazards regression evaluated predictors of first hospitalization over 2 years. RESULTS Among HIV-infected women, VACS Index score (per 5 points) [adjusted hazard ratio (aHR) 1.08; 95% confidence interval (CI): 1.06 to 1.11], Centers for Epidemiologic Studies-Depression (CESD) scores ≥16 (aHR 1.61; 95% CI: 1.30 to 1.99), smoking (aHR 1.26; 95% CI: 1.02 to 1.55), abuse history (aHR 1.52; 95% CI: 1.20 to 1.93), diabetes (aHR 1.63; 95% CI: 1.31 to 2.04), and black race (aHR 1.28; 95% CI: 1.03 to 1.59) increased risk of hospitalization. Among HIV-uninfected women, VACS Index score (aHR 1.08; 95% CI: 1.03 to 1.13), CESD scores ≥16 (aHR 1.38; 95% CI: 1.02 to 1.86), diabetes (aHR 2.15; 95% CI: 1.57 to 2.95), and black race (aHR 1.61; 95% CI: 1.15 to 2.24) predicted subsequent hospitalization. CONCLUSIONS Psychosocial and clinical factors were associated with risk of hospitalization independently of the VACS Index score. Additional research on contextual and psychosocial influences on health outcomes among women is needed. |
| Databáze: | OpenAIRE |
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