Circulating Proteomic Signatures of Chronological Age
| Autor: | Stephen Newhouse, Ana Viñuela, Massimo Mangino, Simon Lovestone, Claire J. Steves, Nicola Voyle, Patrizia Mecocci, Maria Psatha, Martina Sattlecker, Bruno Vellas, Tim D. Spector, Ana M. Valdes, Richard Dobson, Iwona Kłoszewska, Hilkka Soininen, Stephen Williams, Steven J. Kiddle, Alfonso Buil, Magda Tsolaki, Cristina Menni, Sally K. Nelson |
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| Přispěvatelé: | Kiddle, Steven [0000-0003-4350-7437], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Proteomics Male Aging Twins Early development Pleiotrophin Bioinformatics Aptamers Cohort Studies 0302 clinical medicine Framingham Heart Study Medicine Registries Whole blood Aged 80 and over 0303 health sciences education.field_of_study Framingham Risk Score Middle Aged 3. Good health Phenotype Cohort Cytokines Original Article Female Nucleotide Cohort study Adult medicine.medical_specialty Population Nerve Tissue Proteins Blood biomarkers 03 medical and health sciences Internal medicine Matrix Metalloproteinase 12 Humans education Eye Proteins 030304 developmental biology Aged business.industry United Kingdom Geriatrics and Gerontology business Carrier Proteins Insulin-Like Growth Factor Binding Protein 6 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences The Journals of Gerontology Series A: Biological Sciences and Medical Sciences; Vol 70 Menni, C, Kiddle, S J, Mangino, M, Viñuela, A, Psatha, M, Steves, C, Sattlecker, M, Buil, A, Newhouse, S, Nelson, S, Williams, S, Voyle, N, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Lovestone, S, Spector, T D, Dobson, R & Valdes, A M 2015, ' Circulating Proteomic Signatures of Chronological Age ', Journals of Gerontology Series. A, Biological Sciences and Medical Sciences, vol. 70, no. 7, pp. 809-816 . https://doi.org/10.1093/gerona/glu121 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glu121 |
| Popis: | To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent individuals from the AddNeuroMed, Alzheimer's Research UK, and Dementia Case Registry cohorts. Results were further validated using RNAseq data from whole blood in TwinsUK and the most significant proteins were tested for association with aging-related phenotypes after adjustment for age. Eleven proteins were associated with chronological age and were replicated at protein level in an independent population. These were further investigated at gene expression level in 384 females from the TwinsUK cohort. The two most strongly associated proteins were chordin-like protein 1 (meta-analysis β [SE] = 0.013 [0.001], p = 3.66 × 10(-46)) and pleiotrophin (0.012 [0.005], p = 3.88 × 10(-41)). Chordin-like protein 1 was also significantly correlated with birthweight (0.06 [0.02], p = 0.005) and with the individual Framingham 10-years cardiovascular risk scores in TwinsUK (0.71 [0.18], p = 9.9 × 10(-5)). Pleiotrophin is a secreted growth factor with a plethora of functions in multiple tissues and known to be a marker for cardiovascular risk and osteoporosis. Our study highlights the importance of proteomics to identify some molecular mechanisms involved in human health and aging. |
| Databáze: | OpenAIRE |
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