Elevated Prolactin in Pediatric Patients on Typical and Atypical Antipsychotics
| Autor: | Marianne Wudarsky, Rob Nicolson, Jeffrey S. Bedwell, Peter Gochman, Susan D. Hamburger, Judith L. Rapoport, Lori Spechler, Marge Lenane |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Olanzapine Psychosis medicine.medical_specialty Adolescent Gastroenterology Benzodiazepines Sex Factors Double-Blind Method Internal medicine medicine Haloperidol Humans Endocrine system Pharmacology (medical) Child Clozapine Not Otherwise Specified Pirenzepine medicine.disease Prolactin Clinical trial Psychiatry and Mental health Endocrinology Pediatrics Perinatology and Child Health Female Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Journal of Child and Adolescent Psychopharmacology. 9:239-245 |
| ISSN: | 1557-8992 1044-5463 |
| Popis: | As part of systematic treatment trials of haloperidol, clozapine, and olanzapine with a total of 35 children and adolescents with early onset psychosis, prolactin was measured at baseline and week 6 of treatment. The National Institute of Mental Health patients--13 females, 22 males (mean age, 14.1+/-2.3 years; range, 9.1-19 years) with childhood onset schizophrenia (n = 32), or Psychotic Disorder not otherwise specified (NOS) (n = 3) with onset of psychosis before age 13--were recruited for open or double-blind trials of haloperidol, clozapine, or olanzapine. Baseline serum prolactin was measured after a 3-week washout period and after 6 weeks of treatment. Mean prolactin concentration after 6 weeks of treatment was significantly elevated on all three drugs; however, on clozapine, mean prolactin remained within the normal range. Prolactin was increased above the upper limit of normal for 100% of 10 patients on haloperidol, 70% of 10 patients on olanzapine, and 0% of 15 patients on clozapine (chi2 analyses: H > C, p = 0.004; O > C, p = 0.001). Given the potential endocrine and possible cardiac correlates of hyperprolactinemia, these more robust prolactin elevations in pediatric patients after short-term exposure to olanzapine than those reported for adults justify longer observation intervals with bigger samples to establish treatment safety of atypical antipsychotics in adolescents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|