Glaucoma Treatment With Once-Daily Levobunolol
| Autor: | Ronald Gaster, Richard A. Lewis, Jess Smith, Efraim Duzman, Leon G. Partamian, John C. Lue, Thaddeus Wandel, Arthur D. Charap, Gary D. Novack, Stephen Cobb |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Intraocular pressure Adolescent genetic structures Eye disease Levobunolol Glaucoma Timolol Ocular hypertension Drug Administration Schedule Double-Blind Method Actuarial Analysis Heart Rate Heart rate medicine Humans Intraocular Pressure Aged business.industry Middle Aged medicine.disease eye diseases Ophthalmology Blood pressure Anesthesia Drug Evaluation sense organs business medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 101:298-304 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/0002-9394(86)90823-8 |
| Popis: | Although twice-daily instillation of topical beta-blockers is the standard regimen for treatment of increased intraocular pressure, once-daily therapy might improve patient compliance and provide greater safety. In a three-month, double-masked clinical trial, 92 patients with open-angle glaucoma or ocular hypertension received levobunolol 0.5% or 1% or timolol 0.5% once daily, in both eyes. Overall mean decreases in intraocular pressure were significantly greater in the groups treated with levobunolol than in the group treated with timolol. Intraocular pressure decreases averaged 7.0 mm Hg with levobunolol 0.5%, 6.5 mm Hg with levobunolol 1%, and 4.5 mm Hg with timolol. The intraocular pressures of 72% (18 of 25 patients) of those treated with levobunolol 0.5%, 79% (22 of 28 patients) of those treated with levobunolol 1%, and 64% (16 of 25 patients) of those treated with timolol were successfully controlled during the study. Heart rate and blood pressure decreases were minimal with both levobunolol and timolol. Study results indicated that once-daily treatment with levobunolol and, to a lesser extent, timolol is sufficient to control intraocular pressure successfully and safely. |
| Databáze: | OpenAIRE |
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