Cardiac Troponin T
| Autor: | Aldo Clerico, Alma M.A. Mingels, Stephanie T. P. Mezger, Douwe de Boer, Otto Bekers, Wim H. M. Vroemen, Silvia Masotti |
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| Přispěvatelé: | MUMC+: DA CDL Algemeen (9), RS: CARIM - R2.02 - Cardiomyopathy, Imaging Mass Spectrometry (IMS), RS: M4I - Imaging Mass Spectrometry (IMS), MUMC+: DA CDL (5), MUMC+: DA CDL Analytisch cluster 1K (9), MUMC+: DA CDL Toegelatenen (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Faculteit FHML Centraal, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, RS: Carim - H02 Cardiomyopathy |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Applied Laboratory Medicine, 3(5), 909-911. American Association of Clinical Chemistry |
| ISSN: | 2475-7241 2576-9456 |
| Popis: | To the Editor: Vigorous endurance-type exercise causes cardiac troponin T (cTnT)1 elevations that often exceed the diagnostic cutoff value for acute myocardial infarction (AMI) (1). It remains to be investigated whether exercise-induced cTnT release reflects a physiological or pathological process. Our recent studies utilizing multiple protein analysis techniques allowed determination of circulating cTnT forms, and it appeared that these are different in acute vs chronic pathologies (2, 3). In sera of AMI patients, cTnT is degraded from its intact form (estimated molecular weight by SDS-PAGE; MW est, 40 kDa) to primary ( MW est, 29 kDa) and subsequent secondary ( MW est, 14–18 kDa) fragments in a time-dependent manner (2). Only … |
| Databáze: | OpenAIRE |
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