Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer’s Disease: A Systematic Review
| Autor: | Clive Ballard, Emma L. Jones, Byron Creese |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Psychosis
medicine.medical_specialty Hallucinations Cognitive Neuroscience Disease Severity of Illness Index Delusions Alzheimer Disease Severity of illness medicine Humans Dementia Genetic Predisposition to Disease Cognitive impairment Psychiatry Psychiatric Status Rating Scales Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Cognition medicine.disease Psychiatry and Mental health 5 httlpr polymorphism Psychotic Disorders Psychiatric status rating scales Geriatrics and Gerontology Psychology Clinical psychology |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 35:155-164 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000346733 |
| Popis: | Background/Aims: Cognitive impairment is a well-established correlate of psychotic symptoms in Alzheimer’s disease (AD-P). We review whether this relationship has confounded previous genetic association studies of 5HTTLPR and AD-P. Methods: We reviewed all studies on 5HTTLPR and conducted a semi-quantitative analysis. Results: Three out of 4 studies with low MMSE reported a significant association, while 1 out of 4 with high MMSE reported a significant association. Conclusions: Variation in cognitive impairment in past studies has contributed to the inconsistency in findings. The findings presented here bring a greater clarity to our understanding of the role of 5HTTLPR in AD-P. |
| Databáze: | OpenAIRE |
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