Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation
| Autor: | Mehrdad Hamidi, Tahereh Dara, Masoumeh Kurd, Zhila Izadi, Amir Azadi, Maryam Dibaei, Mohammad Sharif Zadeh, Hamid Akbari Javar, Soroor Sadegh Malvajerd |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Curcumin Physiology Cognitive Neuroscience Chemistry Pharmaceutical Biological Availability Biochemistry Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Differential scanning calorimetry Drug Delivery Systems Pharmacokinetics Solid lipid nanoparticle Animals 030304 developmental biology 0303 health sciences Drug Carriers Brain Cell Biology General Medicine Lipids Nanostructures chemistry Nanoparticles Nanocarriers 030217 neurology & neurosurgery Nuclear chemistry |
| Zdroj: | ACS chemical neuroscience. 10(1) |
| ISSN: | 1948-7193 |
| Popis: | Curcumin is a multitherapeutic agent with great therapeutic potential in central nervous system (CNS) diseases. In the current study, curcumin was encapsulated in solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for the purpose of increasing brain accumulation. The preparation processes have been optimized using experimental design and multiobjective optimization methods. Entrapment efficiency of curcumin in SLNs and NLCs was found to be 82% ± 0.49 and 94% ± 0.74, respectively. The pharmacokinetic studies showed that the amount of curcumin available in the brain was significantly higher in curcumin-loaded NLCs (AUC0-t = 505.76 ng/g h) compared to free curcumin (AUC0-t = 0.00 ng/g h) and curcumin-loaded SLNs (AUC0-t = 116.31 ng/g h) (P < 0.005), after intravenous (IV) administration of 4 mg/kg dose of curcumin in rat. The results of differential scanning calorimetry and X-ray diffraction showed that curcumin has been dispersed as amorphous in the nanocarriers. Scanning electron mic... |
| Databáze: | OpenAIRE |
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