High Field Magnetic Resonance Imaging Evaluation of Superparamagnetic Iron Oxide Nanoparticles in a Permanent Rat Myocardial Infarction
| Autor: | Pierre Legras, Benoit Denizot, J-J Le Jeune, Florence Franconi, L. Marescaux, Jean-Paul Saint-André, Laurent Lemaire, Catherine Chapon |
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| Přispěvatelé: | Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Materials science High field magnetic resonance imaging Superparamagnetic iron oxide nanoparticles [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Iron Myocardial Infarction 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication medicine Animals Nanotechnology Radiology Nuclear Medicine and imaging Myocardial infarction Particle Size Rats Wistar ComputingMilieux_MISCELLANEOUS Analysis of Variance Oxides General Medicine medicine.disease Magnetic Resonance Imaging Rats Models Animal Female Radiology Superparamagnetism |
| Zdroj: | Investigative Radiology Investigative Radiology, Lippincott, Williams & Wilkins, 2003, 38 (3), pp.141-146. ⟨10.1097/00004424-200303000-00001⟩ ResearcherID |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/01.rli.0000052979.96332.90 |
| Popis: | The purpose of this study was to evaluate superparamagnetic iron oxide (SPIO) nanoparticles to discriminate infarcted from normal tissue after myocardial infarction using high field MR imaging (7 tesla).Permanent myocardial infarction was induced in rats. SPIO nanoparticles (1 mg Fe/kg) were assessed with T1-weighted gradient echo sequence to visualize the myocardial infarction 48 hours after ligature (n = 6). Furthermore, MR Imaging was performed using a T2-weighted RARE sequence and nanoparticles were injected (5 or 10 mg Fe/kg) on 36 rats 5, 24 or 48 hours after infarction.No changes in contrast between normal and infarcted myocardium was observed after nanoparticle injection on T1-weighted images. However, nanoparticles induced a significant contrast increase between normal and infarcted myocardium on T2-weighted images whatever the delay between infarction and imaging (2.99 +/- 1.66 preinjection vs. 7.82 +/- 1.96 after SPIO injection at a dose of 5 mg Fe/kg 5 hours postinfarction, P = 0.0001).Nanoparticle injection made it possible to discriminate normal from infarcted myocardium on T2-weighted images. However, the high magnetic field prevented the visualization of the T1 effect of SPIO nanoparticles. |
| Databáze: | OpenAIRE |
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