Predictive Value of Amino Acids in the Treatment of Major Depression with Fluvoxamine
| Autor: | C. P C Steinhilber, L.S. Volonteri, V. Laini, Massimo C. Mauri, Marta E. Scalvini, Federica Zamberlan, L. Boscati |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Fluvoxamine Predictive Value of Tests Internal medicine Melancholia medicine Humans Amino Acids Psychiatry Biological Psychiatry Depression (differential diagnoses) Aged chemistry.chemical_classification Analysis of Variance Depressive Disorder Major Mean age Middle Aged Predictive value Amino acid Psychiatry and Mental health Neuropsychology and Physiological Psychology chemistry Predictive value of tests Female Analysis of variance medicine.symptom Psychology Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Neuropsychobiology. 44:134-138 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000054933 |
| Popis: | Sixteen outpatients (mean age ± SD 50.18 ± 11.55 years; 11 females and 5 males) affected by major depression without melancholia (DSM-IV) were included in the study. The control group consisted of 11 healthy volunteers (mean age ± SD 39.90 ± 13.39 years; 2 females and 9 males). Patients were treated with fluvoxamine (FVX) 100–300 mg daily. Clinical assessment was performed using the Hamilton Rating Scales for Anxiety and Depression (HRS-A; HRS-D) and the Clinical Global Impression Scale (CGI) at basal time (T₀), after 4 weeks and after 8 weeks (T8). Plasma and platelet amino acid levels were determined at T₀ in all the subjects and also at T8 in depressed patients. A significant clinical improvement was observed in depressed patients according to the HRS-A (p = 0.004), HRS-D (p = 0.008) and CGI (p = 0.002). A negative correlation (r = –0.53, p = 0.049) was found between platelet levels of valine and HRS-D improvement rate. Patients showed significantly higher tyrosine/large neutral amino acids (LNAAs) and lower tryptophan/LNAAs, ratios which could represent an index of good response to a serotonergic drug like FVX. |
| Databáze: | OpenAIRE |
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