Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
| Autor: | Hettwer, M. D., Larivière, S., Veltman, D. J., Stein, D. J., Franke, B., van Erp, T. G. M., van Rooij, D., van den Heuvel, O. A., Jahanshad, N., Thompson, P. M., Thomopoulos, S. I., Park, B. Y., Bethlehem, R. A. I., Bernhardt, B. C., Eickhoff, S. B., Valk, S. L., Schmaal, L., Andreassen, O. A., Ching, C. R. K., Hoogman, M., Buitelaar, J. |
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| Přispěvatelé: | ENIGMA ADHD Working Group, ENIGMA Autism Working Group, ENIGMA Bipolar Disorder Working Group, ENIGMA Major Depression Working Group, ENIGMA OCD Working Group, ENIGMA Schizophrenia Working Group, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Cerebral Cortex
Multidisciplinary Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] Mental Disorders General Physics and Astronomy General Chemistry Magnetic Resonance Imaging General Biochemistry Genetics and Molecular Biology All institutes and research themes of the Radboud University Medical Center 130 000 Cognitive Neurology & Memory Cerebellum Connectome Humans Attention ddc:500 |
| Zdroj: | ENIGMA ADHD working group, ENIGMA Autism Working Group, ENIGMA Bipolar Disorder Working Group, ENIGMA Major Depression Working Group, ENIGMA OCD Working Group & ENIGMA Schizophrenia Working Group 2022, ' Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders ', Nature Communications, vol. 13, no. 1, pp. 6851 . https://doi.org/10.1038/s41467-022-34367-6 Nature Communications 13(1), 6851 (2022). doi:10.1038/s41467-022-34367-6 Nature Communications Nature Communications, 13 Nature Communications, 13(1). Nature Publishing Group UK Nature Communications, 13, 1 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-022-34367-6 |
| Popis: | Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization. |
| Databáze: | OpenAIRE |
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