Effect of the Periapical 'Inflammatory Plug' on Dental Pulp Regeneration: A Histologic In Vivo Study
| Autor: | Herbert L. Ray, Juan M. Taboas, Qahtan AlQahtani, Samer H. Zaky, Jingming Chen, Avinash Jagannath Patil, Elia Beniash, Charles Sfeir |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Regenerative Endodontics Regenerative endodontics Root canal Dentistry Fibrin Root Canal Filling Materials 03 medical and health sciences 0302 clinical medicine Tooth Apex Dental Pulp Necrosis medicine Dentin Humans Regeneration General Dentistry Dental Pulp Dental Pulp Cavity Periapical periodontitis biology business.industry 030206 dentistry medicine.disease Root Canal Therapy Resorption Cellular infiltration 030104 developmental biology medicine.anatomical_structure biology.protein business Periapical Periodontitis |
| Zdroj: | Journal of Endodontics. 46:51-56 |
| ISSN: | 0099-2399 |
| Popis: | Introduction In the current study, we investigate the effect of the inflammation occupying the apical foramen—a phenomenon we refer to as “inflammatory plug”—on the regenerative potential of a root canal therapy. Methods We performed root canal treatment (RCT) in 12 canine root canals while aseptically instrumenting the apex to a 0.5-mm-wide foramen and obturating the canals with the following materials: collagen sponge, platelet-rich fibrin, and blood clot (no material introduced). Results We were successful in maintaining the integrity of the periapical tissue in 8 of 12 RCTs. Injury to the periapical tissue occurred during the remaining 4 RCTs, which initiated inflammation accompanied by bone and dentin resorption. Our histologic analyses showed that the resulting inflammatory plug contained abundant M1 macrophages and was associated with an absence of intracanal cellular infiltration. On the contrary, noninflamed samples showed signs of repair, as indicated by the migration of periapical cells throughout the root canal. Conclusions We conclude that controlling periapical inflammation is key while attempting to achieve dental pulp regeneration. |
| Databáze: | OpenAIRE |
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