Use of Golden Syrian Hamster as an Animal Model to Study Leptospirosis-Associated Immune Responses
| Autor: | Julie Cagliero, Karl Huet, Mariko Matsui |
|---|---|
| Přispěvatelé: | Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP), Nabuo Koizumi, Mathieu Picardeau |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Syrian hamster animal diseases 030106 microbiology Hamster Disease [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity 03 medical and health sciences Animal model Immune system Leptospira [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Leptospirosis Experimental infection Syrian hamsters Innate immune system biology biology.organism_classification medicine.disease [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology 3. Good health 030104 developmental biology Immunology Gene expression |
| Zdroj: | Leptospira spp. Nabuo Koizumi; Mathieu Picardeau. Leptospira spp., 2134, Springer Science+Business Media, pp.243-255, 2020, Methods in Molecular Biology, 978-1-0716-0458-8. ⟨10.1007/978-1-0716-0459-5_22⟩ Methods in Molecular Biology ISBN: 9781071604588 |
| Popis: | International audience; Experimental infections greatly contribute to further deepen our knowledge of infectious diseases. In the case of leptospirosis, hamsters as well as gerbils and guinea pigs have been used as animal models of acute leptospirosis in studying the pathophysiology of the disease. Here we describe a typical Leptospira infection using golden Syrian hamsters. We will also present techniques we use to study the resulting bacterial burden and gene expression patterns in the host in order to decipher the innate immune response to leptospirosis. |
| Databáze: | OpenAIRE |
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