Altered glucose metabolism in microvessels from patients with Alzheimer's disease
| Autor: | Jeffrey Goldman, Michael L. Freedman, Jean Logan, Alfred P. Wolf, John Pearson, Joanna S. Fowler, David L. Marcus, Jir S. Tsai, David R. Christman, Mony J. de Leon, Kevin Hunter |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
medicine.medical_specialty Deoxyglucose In Vitro Techniques Biology Carbohydrate metabolism Microcirculation chemistry.chemical_compound Degenerative disease Alzheimer Disease Hexokinase Internal medicine Deoxy Sugars medicine Humans Phosphorylation Aged Aged 80 and over medicine.diagnostic_test Metabolism Middle Aged medicine.disease Temporal Lobe Cortex (botany) Endocrinology Neurology chemistry Positron emission tomography Blood Vessels Neurology (clinical) Alzheimer's disease Energy Metabolism |
| Zdroj: | Annals of Neurology. 26:91-94 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410260114 |
| Popis: | Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age-matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism. |
| Databáze: | OpenAIRE |
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