Effects of ellagic acid in the testes of streptozotocin induced diabetic rats
| Autor: | Gulistan Sanem Saribas, Saadet Özen Akarca Dizakar, Akin Tekcan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences World health Streptozocin Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ellagic Acid Internal medicine Diabetes mellitus Testis medicine Animals skin and connective tissue diseases 0105 earth and related environmental sciences Pharmacology Chemical Health and Safety business.industry Public Health Environmental and Occupational Health General Medicine medicine.disease Streptozotocin Rats Antioxidant capacity Oxidative Stress Endocrinology chemistry sense organs business 030217 neurology & neurosurgery Oxidative stress Ellagic acid medicine.drug |
| Popis: | Diabetes mellitus (DM) is a serious and common in the world health problem that leads to different complications. Changes in oxidative stress and antioxidant capacity play an important role in the pathogenesis of DM. The purpose of this study was to investigate ellagic acid (EA) treatment in diabetes induced testicular damage. In our study, 24 male Sprague Dawley rats were divided into four groups. Group 1: Control (n = 6), Group 2: EA (n = 6), Group 3: Diabet (n = 6), Group 4: Diabet + EA (n = 6). Diabetes was induced by intraperitoneal injection of streptozocin (STZ) (55 mg/kg) to group 3 and 4. EA was given 100 mg/kg/day group 2 and 4 for 35 days by oral gavage. We used that Hematoxylen-Eosin (H&E) and Johnsen's scoring to determine histological change. The terminal-deoxynucleoitidyl-transferase mediated nick end-labeling assay (TUNEL) was used for apoptosis. Oxidative stress markers were determined by qRT-PCR and immunexpression of Nrf2 was evaluated in testicular tissue. In conclusion, EA administration on the diabetes model has changed the histopathological features, apopotosis and oxidative stress marker genes in the testis and may have an effect on the reduction of diabetes induced testicular damage. |
| Databáze: | OpenAIRE |
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