The prevention effects of cryptotanshinone nanoemulsion on postoperative peritoneal adhesions
| Autor: | Wang Laiyou, Hou Lian-bing, Wang Chengxi, Qin Linghao, Gu QuLiang, Guo Rishuo |
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| Rok vydání: | 2018 |
| Předmět: |
Male
endocrine system Pharmaceutical Science Tissue Adhesions 02 engineering and technology Pharmacology Peritoneal Diseases 030226 pharmacology & pharmacy Tissue plasminogen activator Postoperative peritoneal adhesions Cell Line Rats Sprague-Dawley 03 medical and health sciences Mice 0302 clinical medicine Postoperative Complications In vivo Drug Discovery Plasminogen Activator Inhibitor 1 medicine Animals Humans Animal study Mice Inbred BALB C Chemistry Fibrinolysis Organic Chemistry Phenanthrenes 021001 nanoscience & nanotechnology Rats Disease Models Animal Surgical Procedures Operative Tissue Plasminogen Activator Nanoparticles Emulsions 0210 nano-technology Plasminogen activator medicine.drug |
| Zdroj: | Drug development and industrial pharmacy. 45(5) |
| ISSN: | 1520-5762 |
| Popis: | The purpose of this study was to prepare a novel cryptotanshinone-loaded nanoemulsion (Cry LN) and to evaluate its prevention effect on the postoperative peritoneal adhesions (PPA). The Cry LN was prepared by high-pressure homogenization method, and various methods were used to investigate the physicochemical properties. The results showed that Cry LN has nanoscale particle size with uniform distribution and could slowly release the incorporated drug compared with Cry solution. With superior safety, Cry LN could increase the ratio of tissue plasminogen activator (tPA)/plasminogen activator inhibitor-1 (PAI-1) up to 673% compared with control group. Furthermore, in vivo animal study confirmed the Cry LN activated the fibrinolytic system and successfully prevented PPA formation in rat. In conclusion, Cry nanoemulsion could be considered as a potentially promising and effective strategy for PPA treatment. |
| Databáze: | OpenAIRE |
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