Mitomycin C and Vinblastine: An Active Regimen in Previously Treated Breast Cancer Patients
| Autor: | Ayala Hubert, Inna Ospovat, Tal Grenader, Nava Siegelmann-Danieli, Tamar Hamburger, Tamar Peretz |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Mitomycin Breast Neoplasms Kaplan-Meier Estimate Vinblastine Gastroenterology 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans 030212 general & internal medicine Antibiotics Antineoplastic business.industry Mitomycin C General Medicine Middle Aged medicine.disease Antineoplastic Agents Phytogenic Regimen Median time 030220 oncology & carcinogenesis Female business Previously treated medicine.drug |
| Zdroj: | Tumori Journal. 95:683-686 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089160909500607 |
| Popis: | Background Metastatic breast cancer has a substantial mortality burden on women worldwide. Presented herein is our experience with the combination of mitomycin-C and vinblastine in heavily pretreated breast cancer patients. Methods Candidates were women with measurable metastatic disease, previously exposed to two or more chemotherapy regimens. Mitomycin-C was given at the dose of 10 mg/mý on day 1 and vinblastine at 6 mg/mý on days 1 and 21 of each 42-day cycle. Analysis included patients exposed to one or more cycles of therapy. Kaplan-Meier curves were used to generate overall survival and time-to-treatment progression curves. Results Forty patients previously exposed to a median of three prior regimens were included. Partial response and stable disease were reported in 14 (35%) and 10 (25%), patients, respectively, for a clinical benefit of 60%. With a median follow-up of 11 months, the median time to progression and survival durations lasted 4 and 12 months, respectively. In a subgroup of 17 women with prior anthracycline and taxane exposure, partial response and stable disease were reported in 4 (23.5%) and 5 (29%), respectively. Treatment was generally well tolerated, with grade 3-4 hematologic and non-hematologic toxicity reported in 8 (20%) and 3 (7.5%) patients, respectively. Two cases of fatalities (5%) occurred with pulmonary toxicity in women heavily exposed to mitomycin-C (cumulative doses of ≥40 mg/mý) and soon after red blood cell transfusion. Conclusions Chemotherapy with mitomycin-C and vinblastine is active and well-tolerated in heavily pretreated breast cancer patients. Caution should be taken to avoid blood transfusion alone with mitomycin-C therapy. |
| Databáze: | OpenAIRE |
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