Changes in serum insulin-like growth factors, not leptin, are associated with postnatal weight gain in preterm neonates

Autor: Wen-Yin Hsu, Fu-Ann Tsai, Hui-Chen Lo, Chiu-Yen Chi, Lon-Yen Tsao
Rok vydání: 2005
Předmět:
Leptin
Male
medicine.medical_specialty
030309 nutrition & dietetics
medicine.medical_treatment
Medicine (miscellaneous)
Nutritional Status
Gestational Age
Weight Gain
Enteral administration
03 medical and health sciences
Insulin-like growth factor
0302 clinical medicine
Insulin-Like Growth Factor II
Somatomedins
Internal medicine
medicine
Birth Weight
Humans
Prealbumin
Insulin-Like Growth Factor I
Serum Albumin
chemistry.chemical_classification
0303 health sciences
Analysis of Variance
Nutrition and Dietetics
biology
Anthropometry
business.industry
Albumin
Infant
Newborn
Insulin-Like Growth Factor Binding Proteins
Transthyretin
Endocrinology
chemistry
Transferrin
Growth Hormone
Multivariate Analysis
biology.protein
030211 gastroenterology & hepatology
Female
Analysis of variance
medicine.symptom
business
Weight gain
Infant
Premature
Zdroj: JPEN. Journal of parenteral and enteral nutrition. 29(2)
ISSN: 0148-6071
Popis: Serum concentrations of conventional nutrition-related proteins, such as albumin, prealbumin, transferrin, and retinol-binding protein, are usually inconsistent with changes in anthropometric measurements in the postnatal period. The aim of this study was to evaluate how reliable growth hormone (GH), insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and leptin, the proteins known to be involved in the regulation of growth, are in reflecting postnatal growth and nutritional status in preterm neonates.Blood samples and anthropometric measurements were collected from 55 preterm neonates (chronological age 30.4 +/- 2.8 weeks) for 4 continuous weeks (weeks 0 to 3).After adjusting for chronological age, body weights and serum IGF-II concentrations were significantly greater and serum transferrin concentrations were significantly lower in weeks 2 and 3 than in week 0 (repeated-measures analysis of variance (ANOVA) and Bonferroni test, p.05). Forward stepwise multivariate regression analysis showed that change in total IGF-I (week 0 to week 3) was a positive predictor, and changes in insulin and prealbumin were negative predictors of postnatal weight gain. In addition, daily fat intake was a positive predictor of postnatal length increases, and changes in prealbumin, insulin, and GH were negative predictors of postnatal changes in the ponderal index (weight x length(-3)). Changes in GH and IGFBP-2 were negative predictors of changes in head circumference and triceps skinfold thickness, respectively.Serial measurements of serum IGF-I and IGF-II may be useful adjuncts to anthropometric measurements for monitoring postnatal growth and nutritional status in preterm neonates.
Databáze: OpenAIRE
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