Elevated Percentage of CD3+ T-Cells and CD4+/CD8+ Ratios in Multiple System Atrophy Patients
Autor: | Yongping Chen, Bei Cao, Qianqian Wei, Hui Liu, Xueping Chen, Lingyu Zhang, Weihua Feng, Huifang Shang |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty disease process CD3 prevalence multiple system atrophy Disease lcsh:RC346-429 Pathogenesis 03 medical and health sciences 0302 clinical medicine Atrophy stomatognathic system Internal medicine parasitic diseases mental disorders medicine lcsh:Neurology. Diseases of the nervous system Original Research biology business.industry medicine.disease nervous system diseases Peripheral cellular immune 030104 developmental biology Endocrinology nervous system Neurology biology.protein Decreased igg Neurology (clinical) Antibody business humoral immune 030217 neurology & neurosurgery CD8 |
Zdroj: | Frontiers in Neurology, Vol 11 (2020) Frontiers in Neurology |
ISSN: | 1664-2295 |
Popis: | α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA and 321 age- and gender-matched healthy controls were included in this study. Lymphocyte subsets, including CD3+, CD4+, and CD8+ cells, and the levels of immunoglobulins IgG, IgM, and IgA were evaluated. The proportions of CD3+ and CD4+ T-lymphocytes were significantly increased in MSA patients compared with those of normal controls. In addition, the ratio of CD4+ to CD8+ cells was significantly increased in male MSA patients and IgG concentrations were decreased in female MSA patients. Furthermore, the concentrations of IgM in female MSA patients were dynamically different at various disease stages and gradually decreased from the early stage until the end stage of the disease (p = 0.029). Other detected immunological indexes were not significantly different during the entire disease course. In this study, high proportions of CD3+ and CD4+ T-lymphocytes and decreased IgG levels were associated with an increased risk for MSA in a Chinese patient population. In addition, PIA may be involved in the progression of MSA. |
Databáze: | OpenAIRE |
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