Liver copper content of rats hypo- or hyperresponsive to dietary cholesterol
| Autor: | Æ Lankhorst, Bert F. M. Van Zutphen, Ingeborg D de Wolf, X.M. Fielmich-Bouman, Hein A. van Lith, Vladimír Křen, Anton C. Beynen, Michal Pravenec, Bernard A. van Oost |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Rat Inbred Strains chemistry.chemical_element Biology Biochemistry Cholesterol Dietary Inorganic Chemistry chemistry.chemical_compound Dry weight Rats Inbred BN Rats Inbred SHR Internal medicine medicine High fat Animals Liver copper Cholesterol Body Weight Whole liver Organ Size Dietary Fats Copper Rats Endocrinology Liver chemistry Molecular Medicine Female Dietary Cholesterol |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 17:177-182 |
| ISSN: | 0946-672X |
| DOI: | 10.1016/s0946-672x(03)80023-8 |
| Popis: | The question addressed is whether cholesterol intake reduces the hepatic copper content in rats. For this purpose we have compared the hepatic copper content of two selected rat inbred strains after feeding the animals a control or a high fat, high cholesterol diet. One strain was dietary cholesterol resistant (SHR/OlaIpcv), whereas the other strain was susceptible to dietary cholesterol (BN- Lx /Cub). Dietary cholesterol-susceptible rats have a lower baseline hepatic copper content when compared with their resistant counterparts. The consumption of a hypercholesterolemic diet decreased the liver copper concentration (expressed in μg/g dry weight) to about the same extent in both strains. However, dietary cholesterol did not reduce the absolute (expressed as μg/whole liver) and relative (expressed as μg/whole liver/100 g body weight) copper store of rats. The decrease of liver copper concentration after the high fat, high cholesterol diet is probably not caused by a decrease in whole hepatic copper content, but rather due to dietary-induced hepatomegaly. |
| Databáze: | OpenAIRE |
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