Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems

Autor: Kenji J. Tsuchiya, Nori Takei, Damee Choi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Postpartum depression
Adult
Male
Genotype
lcsh:Medicine
Gestational Age
Child Behavior Disorders
Interaction
Oxytocin
Polymorphism
Single Nucleotide
Article
Depression
Postpartum
03 medical and health sciences
0302 clinical medicine
Child of Impaired Parents
Pregnancy
medicine
Birth Weight
Humans
Psychology
Genetic Predisposition to Disease
Allele
Child
lcsh:Science
Problem Behavior
Multidisciplinary
business.industry
Mood Disorders
lcsh:R
Infant
Strengths and Difficulties Questionnaire
medicine.disease
Mental health
Oxytocin receptor
030104 developmental biology
Receptors
Oxytocin
Edinburgh Postnatal Depression Scale
Income
Educational Status
Female
Gene-Environment Interaction
lcsh:Q
business
030217 neurology & neurosurgery
Clinical psychology
Follow-Up Studies
Neuroscience
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
ISSN: 2045-2322
Popis: Previous studies have reported interaction effects of oxytocin receptor genotype (rs53576) and environmental factors on mental health in youth. However, the findings are mixed, especially regarding the type of allele (i.e., A vs. G), and it remains unanswered whether such an interaction presents at an early stage of development. Thus, using a unique longitudinal birth cohort sample in Japan (n = 568), we examined whether there was an effect of the interaction between the OXTR rs53576 genotype and maternal postpartum depression, as an environmental risk, on behavioural problems in children. Child behavioural problems (internalising and externalising problems) were ascertained using the Strengths and Difficulties Questionnaire when children were 6 years old. Maternal postpartum depression was measured using the Edinburgh Postnatal Depression Scale when children were at 2 months and 10 months of age. The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype (β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype. This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life. Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje