Additional file 1 of Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Autor: Nell, Rogier J., Menger, Nino V., Versluis, Mieke, Gregorius P. M. Luyten, Verdijk, Robert M., Madigan, Michele C., Jager, Martine J., Velden, Pieter A. Van Der
Rok vydání: 2021
DOI: 10.6084/m9.figshare.14037839.v1
Popis: Additional file 1: Supplementary Table 1. Context sequences, PCR annealing temperatures and supplier information for all assays used. Supplementary Data 1. Methodical overview of all digital PCR experimental setups. Supplementary Figure 1. CYSLTR2 p.L129Q mutation detected by Sanger sequencing of choroidal nevus 12B compared to the reference sequence from a healthy control. Supplementary Figure 2. SNP-array copy number profile and B-allele fractions of the CYSLTR2 mutant melanomas from the TCGA cohort. Supplementary Figure 3. Distribution of arm-level copy number alterations in 77 CYSLTR2 wild-type uveal melanomas from the TCGA cohort. Supplementary Figure 4. Origin of CYSLTR2 expression and characterisation of the immune microenvironment in uveal melanoma based on the single cell RNA expression analysis of the six tumours with > 2% CYSLTR2+ cells.
Databáze: OpenAIRE