Autoimmune thyroiditis after bone marrow transplantation in a boy with Wiskott-Aldrich syndrome
| Autor: | Manuel Bueno, Cristina Fillat, Feliciano J. Ramos, Teresa Olive, José L. Olivares |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Proband
Male Wiskott–Aldrich syndrome Thyroiditis Autoimmune thyroiditis Immune system hemic and lymphatic diseases Immunopathology medicine Humans Transplantation Homologous Amino Acid Sequence Bone Marrow Transplantation Autoimmune disease Chromosomes Human X Base Sequence business.industry Thyroiditis Autoimmune Proteins Hematology Exons medicine.disease Wiskott-Aldrich Syndrome surgical procedures operative medicine.anatomical_structure Oncology Amino Acid Substitution Child Preschool Pediatrics Perinatology and Child Health Immunology Mutation Bone marrow business Wiskott-Aldrich Syndrome Protein |
| Zdroj: | Journal of pediatric hematology/oncology. 24(9) |
| ISSN: | 1077-4114 |
| Popis: | We report a boy with Wiskott-Aldrich syndrome (WAS) who developed autoimmune thyroiditis 19 months after allogenic bone marrow transplantation (BMT). Possible causes of his autoimmune illness were 1) transference of autoimmune cells from the donor, which was ruled out because of the absence of autoimmune illness in his healthy HLA-identical brother (donor); 2) persistent mixed chimerism after BMT ruled out by post-BMT molecular analysis of the proband's peripheral lymphocytes; and 3) patient's predisposition to autoimmune disease secondary to an dysregulated immune system because of WAS and his HLA haplotype. This case brings previously unreported findings to the spectrum of WAS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|