The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
| Autor: | Wayne R. Thomas, Danijela Apostolovic, M. van Hage, Jeanette Grundström, Guro Gafvelin, T. Cirkovic Velickovic, Mirela Curin, Carl Hamsten, K. Waden, Rudolf Valenta, Hans Grönlund, S. Sánchez-Vidaurre |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Models Molecular cat allergy cross-reactivity Protein Conformation Immunology Population dog allergy Lipocalin Cross Reactions Immunoglobulin E medicine.disease_cause Cross-reactivity Epitope 03 medical and health sciences Epitopes 0302 clinical medicine Allergen Dogs medicine Hypersensitivity Immunology and Allergy Animals education Sensitization Antiserum Sweden education.field_of_study biology Chemistry Can f 1 Allergens Molecular biology Lipocalins 3. Good health Basophils 030104 developmental biology medicine.anatomical_structure 030228 respiratory system biology.protein Cats Peptides Fel d 7 |
| Zdroj: | Allergy |
| Popis: | We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients. This is peer-reviewed version of the following article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. [https://doi.org/10.1111/all.12955] Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3651] |
| Databáze: | OpenAIRE |
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