Immunological effects of acute and chronic nicotine administration in rats
| Autor: | Anna L. Miller, Anthony R. Caggiula, Steven Knopf, Leonard H. Epstein, Seymour M. Antelman, Cathy G. McAllister, Kenneth A. Perkins |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Nicotine NICOTINE EXPOSURE Lymphocyte Immunology chemical and pharmacologic phenomena Lymphocyte Activation Rats Sprague-Dawley Internal medicine medicine Splenocyte Immunology and Allergy Animals Lymphocytes Glucocorticoids biology business.industry hemic and immune systems Lymphocyte Subsets Rats Endocrinology medicine.anatomical_structure Neurology Chronic nicotine Concanavalin A Toxicity biology.protein Neurology (clinical) business CD8 medicine.drug |
| Zdroj: | Journal of neuroimmunology. 50(1) |
| ISSN: | 0165-5728 |
| Popis: | We previously demonstrated that acute nicotine administration decreased the response of rat blood leukocytes (PBL) to concanavalin A (ConA). We now extend those findings to a comparison between the effects of acute and prolonged nicotine exposure (ten daily injections), on PBL and splenocytes (SL). A single injection suppressed the PBL response to ConA and phytohemagglutinin (PHA); tolerance developed by ten injections. In contrast, acute nicotine did not affect SL response to ConA and reduced the PHA response only at the highest concentration. Ten nicotine injections enhanced SL responsiveness to PHA. The only change in PBL subsets was an increase in CD8+ cells following ten injections. |
| Databáze: | OpenAIRE |
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