Use of primary human fetal chondroblast culture for xenotransplantation into rat articular cartilage defect
| Autor: | L. G. Burova, S. N. Lukanina, Andrey Valentinovich Sakharov, M. B. Pykhtina, E. I. Ryabchikova, A. A. Makeyev, T. D. Kolokoltseva, A. V. Efremov, V. A. Valeyeva |
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| Rok vydání: | 2009 |
| Předmět: |
Cartilage
Articular Pathology medicine.medical_specialty Primary culture Chondroblast Xenotransplantation medicine.medical_treatment Transplantation Heterologous Articular cartilage General Biochemistry Genetics and Molecular Biology Chondrocytes Fetus medicine Animals Humans Cells Cultured Immune rejection business.industry Cartilage General Medicine Rats medicine.anatomical_structure Human fetal Immunology business |
| Zdroj: | Bulletin of experimental biology and medicine. 146(1) |
| ISSN: | 0007-4888 |
| Popis: | The possibility of xenotransplantation of human fetal chondroblasts was studied. Filling of the rat articular cartilage defect with a tissue-engineering construction based on primary culture of human fetal chondroblasts and chitosan gel caused no immune rejection over 60 days and provided the formation of organotypical regenerate due to proliferation and differentiation of donor fetal chondroblasts and their integration in the recipient cartilage tissue. |
| Databáze: | OpenAIRE |
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