Is Ethanol a Pro-Drug? Acetaldehyde Contribution to Brain Ethanol Effects
| Autor: | Roberta J. Ward, Marco Diana, Etienne Quertemont, Richard R. Bell, Sergey M. Zimatkin, C. J. Peter Eriksson, Pavel S. Pronko, Milena Pisano, Zachary A. Rodd |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Medicine (miscellaneous) Acetaldehyde Toxicology Receptors Dopamine chemistry.chemical_compound Internal medicine medicine Animals Humans Prodrugs Ethanol metabolism Neurons Motivation Ethanol Ventral Tegmental Area Brain Rats Ventral tegmental area Psychiatry and Mental health Endocrinology medicine.anatomical_structure chemistry Psychology Neuroscience |
| Zdroj: | Alcoholism: Clinical & Experimental Research. 29:1514-1521 |
| ISSN: | 0145-6008 |
| DOI: | 10.1097/01.alc.0000175015.51329.45 |
| Popis: | This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde toxicity, by Roberta J. Ward; and (5) Role of acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson. |
| Databáze: | OpenAIRE |
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