Controversial effect on Erk activation of some cytotoxic drugs in human LOVO colon cancer cells
| Autor: | Jihene Elloumi-Mseddi, Bochra Hakim, Abdelhamid Beji, Sami Aifa, Ikram Jemel-Oualha |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Colorectal cancer Morpholines Blotting Western Apoptosis macromolecular substances Pharmacology Biochemistry 03 medical and health sciences 0302 clinical medicine Gastrointestinal Agents Ciprofloxacin Tumor Cells Cultured medicine Humans Topoisomerase II Inhibitors Cytotoxic T cell Extracellular Signal-Regulated MAP Kinases Cytotoxicity Molecular Biology Cell Proliferation Cell growth business.industry Kinase Trimebutine Cell Biology biochemical phenomena metabolism and nutrition medicine.disease In vitro Enzyme Activation 030104 developmental biology 030220 oncology & carcinogenesis Colonic Neoplasms business |
| Zdroj: | Journal of Receptors and Signal Transduction. 36:21-25 |
| ISSN: | 1532-4281 1079-9893 |
| Popis: | The use of some classic antibiotics was recently shown to inhibit growth and to induce apoptosis in human LOVO colon cancer cells. In this study, we describe that ciprofloxacin (CI), trimebutine maleate (COL) and tiemonium methylsulfate (VIS) greatly inhibit cell proliferation in vitro. Proliferation inhibition reached its maximum at 10–4 M, 10–3 M and 10–2 M, respectively, for COL, CI and VIS. Moreover, phospho-extracellular-regulated kinase was totally abrogated in non-apoptotic cytotoxicity of VIS but decreases or increases in the apoptotic inhibition, respectively, of COL and CI treatments.Abbreviations: CI: ciprofloxacin; COL: trimebutine maleate; VIS: tiemonium methylsulfate; MAPK/Erk: mitogen-activated protein kinases/extracellular-regulated kinase |
| Databáze: | OpenAIRE |
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